1-Naphthalenesulfonyl chloride → HCID 15453206, compound

HRID 439361Notes

Reaction equation

HRID 439361 reaction equation
[NH2:1][C:2]1[C:6]([Br:7])=[C:5]([CH3:8])[O:4][N:3]=1.[C:9]1([S:19](Cl)(=[O:21])=[O:20])[C:18]2[C:13](=[CH:14][CH:15]=[CH:16][CH:17]=2)[CH:12]=[CH:11][CH:10]=1>>[Br:7][C:6]1[C:2]([NH:1][S:19]([C:9]2[C:18]3[C:13](=[CH:14][CH:15]=[CH:16][CH:17]=3)[CH:12]=[CH:11][CH:10]=2)(=[O:21])=[O:20])=[N:3][O:4][C:5]=1[CH3:8]

Participants

3

Reactant 2

HCID 665601-Naphthalenesulfonyl chlorideHCID 27744644-Bromo-5-methyl-1,2-oxazol-3-amine

Product 1

HCID 15453206HCID 15453206, compoundYield 51%

Procedure

N-(4-Bromo-5-methyl-3-isoxazolyl)-1 -naphthalenesulfonamide was prepared from 3-amino-4-bromo-5-methylisoxazole and 1-naphthalenesulfonyl chloride as described in Example 2 in 51% yield. Recrystallization from ethyl acetate/hexanes gave a crystalline solid, m.p. 167°-170° C.

Workup

  1. customRecrystallization from ethyl acetate/hexanes
  2. customgave a crystalline solid, m.p. 167°-170° C.

Sources & evidence

ORD record
ord-8456d5ae6472448fbc0d26e33ab70149
Source dataset
uspto-grants-1996_05
Patent number
US05514691

Reaction notes

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