2-Fluorobenzenesulphonyl chloride → HCID 18617302, compound

HRID 439371Notes

Reaction equation

HRID 439371 reaction equation
[NH2:1][C:2]1[O:6][N:5]=[C:4]([CH3:7])[C:3]=1[Br:8].[F:9][C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][C:11]=1[S:16](Cl)(=[O:18])=[O:17]>>[F:9][C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][C:11]=1[S:16]([NH:1][C:2]1[O:6][N:5]=[C:4]([CH3:7])[C:3]=1[Br:8])(=[O:18])=[O:17]

Participants

3

Reactant 2

HCID 1377612-Fluorobenzenesulphonyl chlorideHCID 104875194-Bromo-3-methylisoxazol-5-amine

Product 1

HCID 18617302HCID 18617302, compoundYield 44%

Procedure

2-Fluoro-N-(4-bromo- 3-methyl- 5-isoxazolyl)benzenesulfonamide was prepared from 5-amino-4-bromo-3-methylisoxazole and 2-fluorobenzenesulfonyl chloride according to the procedures described in Example 1b. The crude product was purified by recrystallization from ethyl acetate/hexanes to give a white solid, m.p. 87°-89° C., yield 44%.

Workup

  1. customThe crude product was purified by recrystallization from ethyl acetate/hexanes
  2. customto give a white solid, m.p. 87°-89° C., yield 44%

Sources & evidence

ORD record
ord-48a1f7d11aa04492907c18535a3fcfac
Source dataset
uspto-grants-1996_05
Patent number
US05514691

Reaction notes

Loading…