2-Mesitylenesulfonyl chloride → HCID 15453209, compound

HRID 439376Notes

Reaction equation

HRID 439376 reaction equation
[NH2:1][C:2]1[O:6][N:5]=[C:4]([CH3:7])[C:3]=1[Br:8].[CH3:9][C:10]1[CH:15]=[C:14]([CH3:16])[CH:13]=[C:12]([CH3:17])[C:11]=1[S:18](Cl)(=[O:20])=[O:19]>>[CH3:9][C:10]1[CH:15]=[C:14]([CH3:16])[CH:13]=[C:12]([CH3:17])[C:11]=1[S:18]([NH:1][C:2]1[O:6][N:5]=[C:4]([CH3:7])[C:3]=1[Br:8])(=[O:19])=[O:20]

Participants

3

Reactant 2

HCID 130462-Mesitylenesulfonyl chlorideHCID 104875194-Bromo-3-methylisoxazol-5-amine

Product 1

HCID 15453209HCID 15453209, compoundYield 64%

Procedure

2,4,6-Trimethyl-N-(4-bromo-3-methyl-5-isoxazolyl)benzenesulfonamide was prepared from 5-amino-4-bromo-3-methylisoxazole and 2,4,6-trimethylbenzenesulfonyl chloride according to the procedures described in Example 1 b. The crude product was purified by recrystallization from ethyl acetate/hexanes to give a pink solid, m.p. 92°-95° C., yield 64%.

Workup

  1. customThe crude product was purified by recrystallization from ethyl acetate/hexanes
  2. customto give a pink solid, m.p. 92°-95° C., yield 64%

Sources & evidence

ORD record
ord-91c775b3504c47869578066e1abb6394
Source dataset
uspto-grants-1996_05
Patent number
US05514691

Reaction notes

Loading…