Triethylamine → HCID 11793560, compound

Participants

Reaction Steps

N-Bromosuccinimide (64 mg, 0.35 mmol) and triethylamine (0.072 ml, 0.51 mmol) were added to a solution of N-(3-trifluoromethyl-5isoxazolyl)benzenesulfonamide(100 mg, 0.34 mmol)in chloroform (20 ml) at room temperature. The reaction was stirred at room temperature for 2 h. Chloroform (30 ml) was added and the solution was washed with 1N hydrochloric acid (40 ml), dried over magnesium sulfate and concentrated. The crude product was purified by HPLC to afford 114 mg (90%) N-(4-bromo-3-trifiuoromethyl-5-isoxazolyl)benzenesulfonamide as an off-white solid, m.p. 104°-105° C.

Provenance & Evidence