反应详情

温度

0 °C

To 2-acetamido-5-fluorobenzotrifluoride (1.369 g, 6.19 mmol) in concentrated H2SO4 (6 mL) at 0° C. was added dropwise 70% HNO3 (0.8 mL, Baker). The mixture was stirred at 0° C. for 0.5 h, then at room temperature for 3 h and it was poured into ice water (25 g). The precipitate was collected by filtration, affording 2.1 g of crude 2-acetamido-5-fluoro-3-nitrobenzotrifluoride. It was crystallized from EtOH/H2O to afford 1.50 g of pure compound as yellow needles.

1. waitat room temperature for 3 h
2. filtrationThe precipitate was collected by filtration