Sulfuric Acid → HCID 15429088, compound

HRID 439514Notes

Reaction equation

HRID 439514 reaction equation
[F:1][C:2]1[C:11]([F:12])=[C:10]([F:13])[CH:9]=[C:8]2[C:3]=1[NH:4][C:5](=[O:15])[C:6](=[O:14])[NH:7]2.S(=O)(=O)(O)O.[N+:21]([O-])([O-:23])=[O:22].[K+]>>[N+:21]([C:9]1[C:10]([F:13])=[C:11]([F:12])[C:2]([F:1])=[C:3]2[C:8]=1[NH:7][C:6](=[O:14])[C:5](=[O:15])[NH:4]2)([O-:23])=[O:22]

Participants

4

Reactant 3

HCID 1118Sulfuric AcidHCID 24434Potassium NitrateHCID 108463705,6,7-Trifluoro-1,4-dihydro-2,3-quinoxalinedione

Product 1

HCID 15429088HCID 15429088, compound

Procedure

To 5,6,7-trifluoro-1,4-dihydro-2,3-quinoxalinedione (93 mg, 0.43 mmol) is added concentrated sulfuric acid (0.5 mL). While the flask is an ice bath, KNO3 is slowly added, giving a brown mixture, which is stirred overnight. The reaction mixture, now dark red, is then added into ice water (5 mL), instantly giving an orange precipitate, which is collected by centrifugation. The powder was crystallized from EtOH (5 mL) and dried in vacuo to yield 24 mg (20%) of pale orange microcrystals. 1H NMR (DMSO-d6), 11.9 (br s, 1H), 12.6 (br s, 1H).

Workup

  1. customgiving a brown mixture, which
  2. custominstantly giving an orange precipitate, which
  3. customis collected by centrifugation
  4. customThe powder was crystallized from EtOH (5 mL)
  5. customdried in vacuo
  6. customto yield 24 mg (20%) of pale orange microcrystals

Sources & evidence

ORD record
ord-aa9b59f313ad4e6484ece363c42cf26e
Source dataset
uspto-grants-1996_05
Patent number
US05514680

Reaction notes

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