HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-Fluoro-4-hydroxy-5-methoxybenzaldehyde → N-(3-chlorophenyl)-2-cyano-3-(3-fluoro-4-hydroxy-5-methoxyphenyl) propenamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-Fluoro-4-hydroxy-5-methoxybenzaldehyde | HCID 598452 | — |
| Reactant | N-(3-chlorophenyl)-2-cyanoacetamide | HCID 679494 | — |
| Product | N-(3-chlorophenyl)-2-cyano-3-(3-fluoro-4-hydroxy-5-methoxyphenyl) propenamide | HCID 54180841 | 57% |
Reaction Steps
The reaction was effected in the same manner as in Example 1 with 5-fluorovanillin (410 mg, 2.41 mmol) and N-(3-chlorophenyl) cyanoacetamide (469 mg, 2.41 mmol) to give the objective N-(3-chlorophenyl)-2-cyano-3-(3-fluoro-4-hydroxy-5-methoxyphenyl) propenamide (476 mg, 57% in yield) as yellow powders.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05514711 |
| Source dataset | uspto-grants-1996_05 |
| ORD ID | ord-7fe3ff9d1db443bc88731c55ea01d699 |
| Source note | uspto-grants-1996_05 |