Tetrahydrofuran → HCID 53950865, compound

Participants

Reaction Steps

Under ice-cooling, to a tetrahydrofuran solution of (R)-1-t-butyldimethylsiloxy-2-methoxymethoxy-3-(2-methoxyphenyl)propane (2.2 g) was added a solution of n tetrabutylammoniumfluoride (1 mol/l, 6.46 ml) in tetrahydrofuranand stirred for 2 hours successively. After tetrahydrofuran wasevaporated in vacuo, water was added, extracted with ethyl acetate,and dried over magnesium sulfate. The solvent was evaporated invacuo, the gained crude product was purified by silica gel columnchromatography, and eluted with a mixed solvent of hexane andethyl acetate (1:1, v/v). The fractions containing the desiredproduct were combined and evaporated in vacuo to obtain (R)-2-methoxymethoxy-3-(2-methoxyphenyl)-1-propanol(1.51 g).

Provenance & Evidence