2-Methylbenzenesulfonic acid → HCID 53796187, compound

Participants

Reaction Steps

To a ethanol solution of (S)-2-chloro-3-(4-methoxy-3-nitrophenyl)propionicacid (4.46 g) was added p toluenesulfonicacid (0.38 g) and heated under reflux for 5 hours.After cooled it down, the solvent was evaporated in vacuo. Theresultant suspension solution was extracted by ethyl acetate (50 ml×3).After the ethyl acetate layer was washed with saturated brine,dried over anhydrous sodium sulfate. The solvent was evaporated invacuo, the resultant crude product was purified by silica gel columnchromatography, and eluted with mixture of hexane or ethylacetate (4:1, v/v). The fractions containing the desired productwere combined and evaporated in vacuo to obtain ethyl (S)-2-chloro-3-(4-methoxy-3-nitrophenyl)propionate(4.51 g)

Provenance & Evidence