反应详情

3.56 Grams (20 mmol) of the N-bromosuccinimide was added to a solution consisting of 3.68 g (20.0 mmol) of the 2-butyl-4,5-bis(hydroxymethyl) imidazole, 40 ml of ethanol and 15 ml of dioxane maintained at a temperature of 45° to 50° C. with stirring. The mixture was further reacted at the same temperature for 30 minutes with stirring, and then the solvent was distilled off under reduced pressure. The obtained reaction product was washed with water and was recrystallized from acetonitrile to obtain a pale yellowish scale-like crystalline 2-butyl-4-bromo-5-(hydroxymethyl) imidazole in an amount of 2.36 g (yield, 51%).

1. temperaturemaintained at a temperature of 45° to 50° C.
2. customThe mixture was further reacted at the same temperature for 30 minutes
3. stirringwith stirring
4. distillationthe solvent was distilled off under reduced pressure
5. customThe obtained reaction product
6. washwas washed with water
7. customwas recrystallized from acetonitrile