N-bromobutanimide → HCID 54267854, compound

Participants

Reaction Steps

3.56 Grams (20 mmol) of the N-bromosuccinimide was added to a solution consisting of 4.86 g (20 mmol) of the 2-benzyl-4,5-bis(hydroxymethyl) imidazole, 80 mol of methoxyethanol and 30 ml of dioxane maintained at a temperature of 45° to 50° C. with stirring. The mixture was further reacted at the same temperature for 24 hours with stirring and, then, the solvent was distilled off under reduced pressure. The obtained reaction product was washed with water and was recrystallized from acetonitrile to obtain a 2-benzyl-4-bromo-5-(hydroxymethyl) imidazole in an amount of 2.1 g (yield, 39%).

Provenance & Evidence