HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methanol → HCID 86648845, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methanol | HCID 887 | — |
| Reactant | Methyl cis(+/-)-3-(4-{[(benzyloxy)carbonyl]amino}-3-methoxypiperidin-1-yl)-5-methoxybenzoate | HCID 86648844 | — |
| Catalyst | HCID 178418390 | HCID 178418390 | — |
| Solvent | Ethyl Acetate | HCID 8857 | — |
| Product | HCID 86648845 | HCID 86648845 | — |
Reaction Steps
The same operation as in Example (40e) was performed using methyl cis(±)-3-(4-{[(benzyloxy)carbonyl]amino}-3-methoxypiperidin-1-yl)-5-methoxybenzoate obtained in Example (257b) (106 mg, 0.25 mmol), a 10% palladium-carbon catalyst (42 mg), methanol (2 mL) and ethyl acetate (2 mL), to obtain the title compound. The resulting compound was used for the next reaction without purification.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08536197B2 |
| Source dataset | uspto-grants-2013_09 |
| ORD ID | ord-b1c0dda8fbf242aba0ea2f59675c1d3b |
| Source note | uspto-grants-2013_09 |