4-(4-Ethyl-4-phenyl-4-silacyclohexyl)cyclohexanone → HCID 178477598, compound

HRID 439635Notes

Reaction equation

HRID 439635 reaction equation
C([Si:3]1([C:16]2[CH:21]=CC=CC=2)[CH2:8][CH2:7][CH:6]([CH:9]2[CH2:14][CH2:13][C:12](=O)[CH2:11][CH2:10]2)[CH2:5][CH2:4]1)C.[F:22][C:23]1[CH:24]=[C:25]([Mg]Br)[CH:26]=[CH:27][C:28]=1[F:29]>>[CH2:16]([Si@H:3]1[CH2:4][CH2:5][C@H:6]([C:9]2[CH:10]=[CH:11][C:12]([C:26]3[CH:25]=[CH:24][C:23]([F:22])=[C:28]([F:29])[CH:27]=3)=[CH:13][CH:14]=2)[CH2:7][CH2:8]1)[CH3:21]

Participants

3

Reactant 2

HCID 224125204-(4-Ethyl-4-phenyl-4-silacyclohexyl)cyclohexanoneHCID 178505835HCID 178505835, compound

Product 1

HCID 178477598HCID 178477598, compound

Procedure

The general procedure of Example 12 was repeated using 30.2 g of 4-(4-ethyl-4-phenyl-4-silacyclohexyl)cyclohexanone and 3,4-difluorophenylmagnesium bromide, thereby obtaining the captioned compound.

Workup

  1. customobtaining the captioned compound

Sources & evidence

ORD record
ord-551378db81134c5790583c9b4fbeecb2
Source dataset
uspto-grants-1996_05
Patent number
US05514824

Reaction notes

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