反应详情

A mixture of ethyl 4-cyano-6,7-dihydro-1,3-dimethyl-1H-indazole-5-carboxylate (13.5 g, 55.0 mmol), o-chloranil (16.3 g, 66.0 mmol) and dry benzene is stirred for 1.5 hours at reflux temperature, cooled and filtered. The filtrate is concentrated in vacuo, filtered through two pads of neutral alumina and evaporated to dryness to afford a yellow solid. Recrystallization from ethyl acetate affords the title product (6.33 g, 47.2%), mp 170°-175.5° C.

1. temperatureat reflux temperature
2. temperaturecooled
3. filtrationfiltered
4. concentrationThe filtrate is concentrated in vacuo
5. filtrationfiltered through two pads of neutral alumina
6. customevaporated to dryness
7. customto afford a yellow solid
8. customRecrystallization from ethyl acetate