Sulfuric Acid → HCID 22402930, compound

Participants

Reaction Steps

A mixture of methyl 4-(4-isopropyl-4-methyl-5-oxo-2-imidazolin-2-yl)-1,3-dimethyl-1H-indazole-5-carboxylate (0.310 g, 0.905 mmol), 2N sodium hydroxide (0.91 mL, 1.82 mmol) and tetrahydrofuran (11 mL) is stirred for 1.5 hours at 42°-52° C., cooled in an ice bath, acidified to pH 3-3.5 with 5N sulfuric acid and extracted with chloroform. The organic extract is dried (Na2SO4) and concentrated in vacuo to give a residue which is recrystallized from acetonitrile to afford the title product as a white solid (0.160 g, 53.2%), mp 156.5°-166° C.

Provenance & Evidence