Methanol → HCID 178509248, compound

HRID 439780Notes

Reaction equation

HRID 439780 reaction equation
[NH2:1][C:2]1[N:3](C(=O)N)[N:4]=[CH:5][C:6]=1[C:7]1[CH:12]=[CH:11][C:10]([CH2:13][C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=2)=[CH:9][CH:8]=1.[OH-].[Na+].CO>O>[NH2:1][C:2]1[C:6]([C:7]2[CH:8]=[CH:9][C:10]([CH2:13][C:14]3[CH:15]=[CH:16][CH:17]=[CH:18][CH:19]=3)=[CH:11][CH:12]=2)=[CH:5][NH:4][N:3]=1

Participants

5

Reactant 3

HCID 887MethanolHCID 14798Sodium HydroxideHCID 152804693-Amino-4-(4-benzylphenyl)-2-carbamoylpyrazole

Product 1

HCID 178509248HCID 178509248, compoundYield 90.3%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

A mixture of 3-amino-4-(4-benzylphenyl)-2-carbamoylpyrazole (1.00 g), sodium hydroxide (1.00 g), methanol (40 ml) and water (40 ml) was stirred under heating reflux for 3.5 hours, and ice-water was added. The mixture was extracted with chloroform, washed with water, dried over Glauber's salt, and concentrated under reduced pressure to give the title compound (0.77 g).

Workup

  1. temperatureunder heating
  2. temperaturereflux for 3.5 hours
  3. extractionThe mixture was extracted with chloroform
  4. washwashed with water
  5. dry with materialdried over Glauber's salt
  6. concentrationconcentrated under reduced pressure

Sources & evidence

ORD record
ord-8990010222cb4a309c7d21d5ba9a9a57
Source dataset
uspto-grants-1996_05
Patent number
US05516777

Reaction notes

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