Aniline → HCID 178424830, compound

Participants

Reaction Steps

A mixture of 6-carboxy-7-hydroxy-3-[4-(3-methylphenylmethyl) phenyl]pyrazolo[1,5-a]pyrimidine (1.44 g) and aniline (10 ml) was heated at 100° C. to 110° C. with stirring, and reacted with each other for 1 hour. After completion of reaction, ice-water (100 ml) was poured into the mixture, and the precipitate was filtrated, washed with water and 30% methol, dried, and separated and purified by using a silica-gel column chromatography (chloroform:methanol=30:1) to give the title compound (0.50 g).

Provenance & Evidence