Diethyl (ethoxymethylene)malonate → HCID 178469481, compound

Participants

Reaction Steps

To a solution of 3-amino-4-[4-(3,4-methylenedioxyphenylmethyl) phenyl]pyrazole (1.5 g) in ethanol (10 ml) was added diethyl ethoxymethylenemalonate (2.07 ml), and the mixture was heated and refluxed for 12 hours. To the mixture was added sodium methoxide (829 mg) under ice-cooling, and the mixture was stirred at room temperature for 1 day. The solvent was distilled away under reduced pressure, and thereto was added water (50 ml) under ice-cooling. The mixture was adjusted to acid with 10% hydrochloric acid, and the precipitate was separated by filtraltion, washed with water to give the title compound (2.1 g) at a quantitative yield.

Provenance & Evidence