HuagongsheHuagongshe Chemistry Print Report · For research reference only
Tramadol → Desmetramadol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Tramadol | HCID 33741 | — |
| Reactant | (-)-(S,S)-trans-Tramadol | HCID 667511 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | Desmetramadol | HCID 9838803 | — |
Reaction Steps
To prepare the (+) enantiomer of the title compound, the reaction was run under the same conditions except that (+)-tramadol as the free base was used instead of the (-)-tramadol to yield 2.8 g of the (+) enantiomer of O-desmethyl tramadol (mp. 242°-3° C.) [α]D25 =+32.2 (C=1, EtOH).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05516803 |
| Source dataset | uspto-grants-1996_05 |
| ORD ID | ord-c596480aa826418092da72728be5c27f |
| Source note | uspto-grants-1996_05 |