HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium Bicarbonate → (S)-Benzyl piperidine-2-carboxylate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium Bicarbonate | HCID 516892 | — |
| Reactant | Benzyl piperidine-2-carboxylate | HCID 12436232 | — |
| Solvent | Ethyl Acetate | HCID 8857 | — |
| Product | (S)-Benzyl piperidine-2-carboxylate | HCID 12436231 | — |
Reaction Steps
Benzyl pipecolate was routinely generated by treating an ethyl acetate suspension of this salt with saturated sodium bicarbonate until dissolution of the organic material. The aqueous layer was extracted twice with ethyl acetate and the combined organic extracts were dried with MgSO4 and evaporated to yield (S)-Benzyl pipecolate (133) as a pale yellow oil.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05516797 |
| Source dataset | uspto-grants-1996_05 |
| ORD ID | ord-a1a196c1d37c4c3f9bf2e3b0eeb99535 |
| Source note | uspto-grants-1996_05 |