Ammonium Acetate → HCID 14855722, compound

Participants

Reaction Steps

0.8 g (2.1 mmol) 2-(1H-indol-3-yl)-3-(5,6-methylenedioxy-1H-indol-3-yl)-maleic acid anhydride, together with 20 g ammonium acetate, are heated for 1 hour to 140° C. (melt). After cooling, the reaction mixture is mixed with water and the red-brown precipitate obtained is filtered off with suction. For purification, it is chromatographed on silica gel with dichloromethane/ethyl acetate (3:1 v/v) as elution agent. There is obtained 0.40 g (45% of theory) 2-(1H-indol-3-yl)-3-(5,6-methylenedioxy-1H-indol-3-yl) -maleinimide in the form of red crystals; m.p. 150° C. (decomp.); RF=0.4 (methylene chloride/ethyl acetate 3:1 v/v).

Provenance & Evidence