反应详情

In one embodiment the trans-1-amino-2-hydroxycyclopentane may be trans-1-amino-2-indanol. If the trans-1-amino-2-hydroxycyclopentane is trans-(1S,2S)-amino-2-indanol, it is converted to cis-(1S, 2R)-1-amino-2-indanol; if the trans-1-amino-2-hydroxycyclopentane is trans-(1R,2R)-1-amino-2-indanol, it is converted to cis-(1R,2S)-l-amino-2-indanol. When the amino alkanol is partially resolved trans-1-amino-2-indanol and the amide is a benzamide, an additional step of recrystallizing the benzamide produces substantially optically pure trans-1-benzamido-2-indanol.

1. customan additional step of recrystallizing the benzamide