HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Hydroxybenzaldehyde → 4-[3-(Tetrahydro-2H-pyran-2-yloxy)propoxy]benzaldehyde
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Hydroxybenzaldehyde | HCID 126 | — |
| Reactant | Tetrabutylammonium Hydroxide | HCID 2723671 | — |
| Reactant | 3-(4-Methylphenyl)sulfonyl-1-tetrahydropyranyloxypropane | HCID 22076178 | — |
| Reactant | Sodium hydroxide methylene chloride | HCID 23721229 | — |
| Product | 4-[3-(Tetrahydro-2H-pyran-2-yloxy)propoxy]benzaldehyde | HCID 22410942 | — |
Reaction Steps
In accordance with literature directions 4-hydroxybenzaldehyde is reacted with the bromo compound 2a in the presence of a phase transfer catalyst (dichloromethane/sodium hydroxide solution/tetra-n-butylammonium hydroxide). After chromatographic purification the aldehyde is obtained as a pale yellow oil.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05517350 |
| Source dataset | uspto-grants-1996_05 |
| ORD ID | ord-655b5f4a24d341b0b2cc29bcb4e57669 |
| Source note | uspto-grants-1996_05 |