Sodium Chloride → HCID 53909514, compound

Participants

Reaction Steps

192 g (1.2 mol) of the obtained 3-hydroxypropoxy methylstyrene and 55 ml of dehydrated and purified pyridine were charged into a 300 ml four-necked flask, and 108 g (0.4 mol) of phosphorus tribromide was dropwise added thereto while maintaining the mixture at -10° C. with dry ice ethanol. After completion of the dropwise addition, the mixture was stirred at room temperature for 15 hours. The reaction mixture was poured into 250 ml of an aqueous sodium chloride solution (20 wt %) and extracted with toluene. The organic layer was washed with water and a 8% sodium hydrogencarbonate aqueous solution and dried over magnesium sulfate. Then, toluene was distilled off under reduced pressure. The solution thereby obtained was subjected to vacuum distillation (b.p. 90° to 91° C./54 Pa) in the presence of DPPH to obtain 3-bromopropoxymethylstyrene as the desired product. The yield was 35%. The obtained solution was analyzed by 1H-NMR and IR spectrum.

Provenance & Evidence