HuagongsheHuagongshe Chemistry Print Report · For research reference only
Dimethylformamide → 2,4,5-Trifluoro-3-difluoromethoxybenzoyl chloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Dimethylformamide | HCID 6228 | — |
| Reactant | Thionyl Chloride | HCID 24386 | — |
| Reactant | 3-(Difluoromethoxy)-2,4,5-trifluorobenzoic acid | HCID 15023781 | — |
| Solvent | Toluene | HCID 1140 | — |
| Product | 2,4,5-Trifluoro-3-difluoromethoxybenzoyl chloride | HCID 15282971 | — |
Reaction Steps
In 37 ml of toluene was dissolved 30 g (0.124 mole) of 2,4,5-trifluoro-3-difluoromethoxybenzoic acid, and 35 ml of thionyl chloride and 0.5 ml of N,N-dimethylformamide were added thereto. The mixture was refluxed by heating for 4 hours. After the reaction, toluene and excess thionyl chloride were removed under reduced pressure to obtain 2,4,5-trifluoro-3-difluoromethoxybenzoyl chloride.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05519016 |
| Source dataset | uspto-grants-1996_05 |
| ORD ID | ord-b7a4b69d09c84c799384e5db63529b5b |
| Source note | uspto-grants-1996_05 |