反应详情

In 110 ml of ethanol was dissolved 3.9 g (0.0125 mole) of 4- (4,6-dimethoxy-2-pyrimidinyl)- 1-benzylpiperazine obtained as described above, and 2.5 g of 5% palladium carbon was added thereto. While refluxing the mixture under heating, hydrogen gas was passed for 6 hours. The reaction mixture was cooled to room temperature and then filtered. The filtrate was concentrated under reduced pressure, and the residue was applied to silica gel column chromatography (the eluent used was a mixture of chloroform: methanol = 9 : 1) to obtain 1.38 g of 1-(4,6-dimethoxy-2-pyrimidinyl)piperazine as pale red crystals.

1. customobtained
2. additionwas added
3. temperatureWhile refluxing the mixture
4. temperatureunder heating
5. filtrationfiltered
6. concentrationThe filtrate was concentrated under reduced pressure
7. additiona mixture of chloroform