HuagongsheHuagongshe Chemistry Print Report · For research reference only
Dimethylformamide → 3-Methoxyphenylacetyl chloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Dimethylformamide | HCID 6228 | — |
| Reactant | (3-Methoxyphenyl)acetic acid | HCID 15719 | — |
| Reactant | Oxalyl chloride | HCID 65578 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 3-Methoxyphenylacetyl chloride | HCID 2733246 | — |
Reaction Steps
An excess of oxalyl chloride was added dropwise to a stirred mixture of 3-methoxyphenylacetic acid (33.2 g), DMF (4 ml) and methylene chloride (800 ml) and the mixture was stirred at ambient temperature for 65 hours. The mixture was evaporated to leave 3-methoxyphenylacetyl chloride (39.6 g).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05519022 |
| Source dataset | uspto-grants-1996_05 |
| ORD ID | ord-bea7fa7cc92a40af8bc845068b596097 |
| Source note | uspto-grants-1996_05 |