Triphenylphosphine → HCID 22406566, compound

Participants

Reaction Steps

A solution of tert-butyl-2-allyloxycarbonylamino-3-tertbutoxy-5-thiophenecarboxylate (1.64 g, 4.62 mmol) in anhydrous THF (50 ml) was treated with PPh3 (240 mg, 0.923 mmol), dimedone (1.3 g, 9.23 mmol) and Pd(PPh3)4 (300 mg, 0.277 mmol). After 30 minutes, the solvent was evaporated, and the residue purified by flash silica-gel chromatography, eluting with petroleum ether: ether (80:20), to give the title compound (975 mg, 98%).

Provenance & Evidence