HCID 22407001, compound → HCID 22406996, compound

Participants

Reaction Steps

Jones' reagent (0.14 mL, 0.39 mmol, 2.67M) was added dropwise to a 0° C. solution of 2-(1-hydroxy-2-(methoxymethoxy)ethyl)-5-thiazole sulfonamide (0.086 g, 0.32 mmol) in acetone (1 mL). The ice bath was removed and the solution stirred for 15 min. The reaction was incomplete an additional 0.07 mL of Jones' reagent was added and the reaction stirred for 15 more minutes. The reaction was quenched with a few drops of isopropanol and the acetone removed in vacuo. The residue was taken up in water and extracted with EtOAc. The combined extracts were dried (MgSO4), concentrated and purified by flash chromatography using 55% EtOAc/hexane to give 4.8 mg (5.3%) of 2-(2-(methoxymethoxy)ethanoyl)-5-thiazole sulfonamide.

Provenance & Evidence