2,3-Dichloro-5,6-dicyano-1,4-benzoquinone → HCID 54515806, compound

Participants

Reaction Steps

A mixture of 100 mg of 3β-hydroxy-16-oxaandrost-5-en-17-one, 370 mg of 2,3-dichloro-5,6-dicyano-1,4-benzoquinone and 10 ml of dioxane was refluxed overnight. After completion of the reaction, the insoluble matters were removed by filtration, and the filtrate was flowed into an activated alumina layer and eluted with methylene chloride. The solvent was distilled out, and the resultant crude product was purified by TLC [developing solvent; chloroform: acetone (19:1)] to obtain 48 mg of 16-oxaandrosta-1,4,6-triene-3,17-dione.

Provenance & Evidence