Chloroform methanol → HCID 53659667, compound

HRID 440438Notes

Reaction equation

[CH3:1][C@:2]12[CH2:19][CH2:18][C@H:17]3[C@@H:7]([CH2:8][CH2:9][C:10]4[C@:15]3([CH3:16])[CH:14]=[CH:13][C:12](=[O:20])[CH:11]=4)[C@@H:6]1[CH2:5][NH:4][C:3]2=[O:21].[CH:22](Cl)(Cl)Cl.CO>>[CH2:22]=[C:9]1[C:10]2[C@:15]([CH3:16])([CH:14]=[CH:13][C:12](=[O:20])[CH:11]=2)[C@@H:17]2[C@H:7]([C@H:6]3[C@@:2]([CH2:19][CH2:18]2)([CH3:1])[C:3](=[O:21])[NH:4][CH2:5]3)[CH2:8]1

Participants

Reactant 2

HCID 21584188Chloroform methanol

HCID 54075728HCID 54075728, compound

Product 1

HCID 53659667HCID 53659667, compound

Procedure

The procedures of Example 14 were repeated using 21 mg of 16-azaandrosta-1,4-diene-3,17-dione in place of 16-oxaandrosta-1,4-diene-3,17-dione, and the resultant crude product was purl fie d by TLC [developing solvent; chloroform: methanol (9:1 )] to obtain 2 mg of 6-methylene-16-azaandrosta-1,4-diene-3,17-dione.

Sources & evidence

ORD record: ord-f225389327bf45c6853a4f7c34b73da7
Source dataset: uspto-grants-1996_05
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05519051

Reaction notes

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