HuagongsheHuagongshe Chemistry Print Report · For research reference only
Oxygen → 1,3-dihydro-3-hydroxy-1-(1-piperidinyl)-3-(4-pyridinyl methyl)-2H-indol-2-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Oxygen | HCID 977 | — |
| Reactant | Sodium hydride | HCID 24758 | — |
| Reactant | 1,3-dihydro-1-(piperidinyl)-3-(4-pyridinylmethyl)-2H-indol-2-one | HCID 23353964 | — |
| Product | 1,3-dihydro-3-hydroxy-1-(1-piperidinyl)-3-(4-pyridinyl methyl)-2H-indol-2-one | HCID 23353968 | 25% |
Reaction Steps
1,3-dihydro-1-(1-piperidinyl)-3-(4-pyridinyl methyl)-2H-indol-2-one could be reacted with sodium hydride and oxygen as reported in Example 22. After column chromatography, the product was recrystallized from hexane-chloroform to give the product as a brown solid, m.p. 156°-158° C. in 25% yield. High Res. Mass Spec. Calcd. for C19H21N3O2 : 324.1712(M+H). Found: 324.1709.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05519132 |
| Source dataset | uspto-grants-1996_05 |
| ORD ID | ord-640be9250abb46189b1a913fb8042142 |
| Source note | uspto-grants-1996_05 |