Maleic Acid → HCID 67681265, compound

Participants

Reaction Steps

A solution of 1-[1-(2-chlorophenyl)cyclopropyl]-6-fluoro-7-hydroxy-2-methyl-1,2,3,4-tetrahydroisoquinoline hydrobromide (1 g, prepared in a similar manner to that described in Example 61) in ethyl acetate (30 ml) was mixed with a solution of maleic acid (0.24 g) in ethyl acetate (8 ml) and the mixture warmed to form a solution. The solution was cooled to yield 1-[1-(2-chlorophenyl)cyclopropyl]-6-fluoro-7-hydroxy-2-methyl-1,2,3,4-tetrahydroisoquinoline maleate, m.p. 183°-184° C. Yield 0.9 g.

Provenance & Evidence