Hydrochloric Acid → HCID 22406853, compound

Participants

Reaction Steps

A mixture of 7-benzyloxy-6-methoxy-2-methyl-1-[1-(4-trifluoromethoxyphenyl)cyclobutyl]-1,2,3,4-tetrahydroisoquinoline hydrochloride (2.94 g), industrial methylated spirits (65 ml) and concentrated hydrochloric acid (65 ml) was heated under reflux for 45 minutes. The mixture was concentrated, and dried by azeotropic distillation with propan-2-ol. The residue was dissolved in ether and treated with one equivalent of oxalic acid to yield 7-hydroxy-6-methoxy-2-methyl-1-[1-(4-trifluoromethoxyphenyl)cyclobutyl]-1,2,3,4-tetrahydroisoquinoline oxalate which was crystallised from acetonitrile.

Provenance & Evidence