反应详情

温度

80 °C

Reduced iron (10.6 g) was added portionwise mixture of 4-{2-[2-(2-chlorophenyl)-5-methyl-4-oxazolyl]ethoxy}nitrobenzene (22.9 g), acetic acid (150 ml) and water (50 ml) at 70° C. After stirring at 80° C. for 2 hours, the insoluble matter was filtered off, and the filtrate was concentrated under reduced pressure. Water was added to the filtrate, and the aqueous mixture was extracted with ethyl acetate. The ethyl acetate layer was washed with water, dried (MgSO4) and concentrated to give 4-{2-[2-(2-chlorophenyl)-5-methyl-4-oxazolyl]ethoxy}aniline as a crude oily material (20.5 g, 97.6%). NMR δppm in CDCl3 : 2.35(3H, s), 2.93(2H, t, J=7 Hz), 3.77(2H, s), 4.15(2H, t, J=7 Hz), 6.56(2H, d, J=9 Hz), 6.75(2H, d, J= 9 Hz), 7.2 to 7.5(3H, m), 7.9 (1H, m).

1. filtrationthe insoluble matter was filtered off
2. concentrationthe filtrate was concentrated under reduced pressure
3. additionWater was added to the filtrate
4. extractionthe aqueous mixture was extracted with ethyl acetate
5. washThe ethyl acetate layer was washed with water
6. dry with materialdried (MgSO4)
7. concentrationconcentrated