反应详情

A mixture of 7-benzyloxy-1-[1-(2-chlorophenyl)cyclopropyl]-6-methoxy-1,2,3,4-tetrahydroisoquinoline (2.1 g, free base liberated from the hydrobromide salt prepared in a similar manner to that described in Example RC14), acetone (30 ml), anhydrous potassium carbonate (1.6 g) and 2-methoxyethyl bromide (2.1 g) was heated under reflux for 6 hours. After a further 16 hours at ambient temperature, potassium carbonate (3 g) and 2-methoxyethyl bromide (2.22 g) were added, and heating continued for 6 hours. The mixture was filtered, the residue washed with acetone, and solvent removed from the filtrate in vacuo to yield 7-benzyloxy-1-[1-(2-chlorophenyl)cyclopropyl]-6-methoxy-2-(2-methoxyethyl)-1,2,3,4-tetrahydroisoquinoline as an oil.

1. customprepared in a similar manner to that
2. temperaturewas heated
3. temperatureunder reflux for 6 hours
4. temperatureheating
5. waitcontinued for 6 hours
6. filtrationThe mixture was filtered
7. washthe residue washed with acetone, and solvent
8. customremoved from the filtrate in vacuo