反应详情

A mixture of 7 -benzyloxy-1-[1-(2 -chlorophenyl)cyclopropyl]-6-methoxy-1,2,3,4-tetrahydroisoquinoline (2.83 g, liberated from the hydrobromide salt prepared in a similar manner to that described in Example RC14), acetone (40 ml), anhydrous potassium carbonate (5.5 g) and 2-bromoethanol (3.6 ml) was heated under reflux for 18 hours. The mixture was filtered, the solids washed with acetone, and the filtrate solvent removed in vacuo to give 7-benzyloxy-1-[1-(2-chlorophenyl)cyclopropyl]-2-(2-hydroxyethyl)-7-methoxy-1,2,3,4-tetrahydroisoquinoline as an oil.

1. customprepared in a similar manner to that
2. temperaturewas heated
3. temperatureunder reflux for 18 hours
4. filtrationThe mixture was filtered
5. washthe solids washed with acetone
6. customthe filtrate solvent removed in vacuo