Phosphorus oxychloride → HCID 22406737, compound

Participants

Reaction Steps

A mixture of N-[2-(2-methoxy-5-biphenylyl)ethyl]-1-(2-chlorophenyl)cyclobutane carboxamide (12.5 g, prepared as described in Example E30), phosphorus oxychloride (25 ml) and acetonitrile (150 ml) was heated under reflux for 6 hours. The solvent was removed by distillation and the residue added to a mixture of ice and water. The mixture was extracted with dichloromethane to yield a solid which was recrystallised from propan-2-ol to give 1-[1-(2-chlorophenyl)cyclobutyl]-7-methoxy-6-phenyl-3,4-dihydroisoquinoline, m.p. 149°-152° C.

Provenance & Evidence