HCID 22406880, compound → HCID 22406730, compound

Participants

Reaction Steps

A mixture of N-[2-(4-methoxyphenyl)ethyl]-1-(2-chlorophenyl)cyclopropanecarboxamide (2 g, prepared in a similar manner to that described in Example D8) and polyphosphate ester (20 ml) was gently heated for 12 hours. The mixture was poured into water and washed with ether, then ethyl acetate. The aqueous phase was basified with aqueous ammonia solution and extracted with ethyl acetate. The extract yielded a solid which was recrystallised from cyclohexane to give 1-[1-(2-chlorophenyl)cyclopropyl]-7-methoxy-3,4-dihydroisoquinoline.

Provenance & Evidence