HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → 1-(4-Methoxyphenyl)cyclobutane-1-carboxylic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Water | HCID 962 | — |
| Reactant | Diethylene Glycol | HCID 8117 | — |
| Reactant | Potassium Hydroxide | HCID 14797 | — |
| Reactant | 1-(4-Methoxyphenyl)cyclobutane-1-carbonitrile | HCID 21902098 | — |
| Product | 1-(4-Methoxyphenyl)cyclobutane-1-carboxylic acid | HCID 16769946 | — |
Reaction Steps
A mixture of 1-(4-methoxyphenyl)cyclobutane carbonitrile (41 g), potassium hydroxide (20 g) and diethylene glycol (160 ml) was heated under reflux for 3.5 hours. The mixture was added to water, acidified with dilute hydrochloric acid and extracted with ether. The extract yielded 1-(4-methoxyphenyl)cyclobutane carboxylic acid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05519034 |
| Source dataset | uspto-grants-1996_05 |
| ORD ID | ord-b88dba37139741bea049d5b66a6142bf |
| Source note | uspto-grants-1996_05 |