反应详情

A mixture of 1-(1-naphthyl)cyclopropanecarbonitrile (60.7 g, prepared in a similar manner to that described in Example N9) and 10% aqueous potassium hydroxide solution was stirred and heated under reflux for 16 hours. Ethylene glycol (250 ml) was added and the mixture was heated under reflux for 5 hours. Each time complete solution was achieved, further water was added to cloud point. Water (500 ml) was added and the mixture was allowed to stand for 16 hours. The resulting solid was removed by filtration. The filtrate was diluted with water (800 ml), filtered, and the filtrate acidified by addition of dilute hydrochloric acid. The resulting solid was collected by filtration, washed with water and dried in air, yielding 1-(1-naphthyl)cyclopropane carboxylic acid (25.9 g).

1. customprepared in a similar manner to that
2. temperatureheated
3. temperatureunder reflux for 16 hours
4. temperaturethe mixture was heated
5. temperatureunder reflux for 5 hours
6. customThe resulting solid was removed by filtration
7. additionThe filtrate was diluted with water (800 ml)
8. filtrationfiltered
9. additionthe filtrate acidified by addition of dilute hydrochloric acid
10. filtrationThe resulting solid was collected by filtration
11. washwashed with water
12. customdried in air