Dimethyl Sulfoxide → HCID 54075573, compound

Participants

Reaction Steps

A mixture of 2-chlorophenylacetonitrile (26.5 g), 1,3-diiodo-2,2-dimethylpropane (56 g) and dimethyl sulphoxide (300 ml) was added dropwise to a stirred suspension of powdered potassium hydroxide (40 g) in dry dimethylsulphoxide (300 ml). The mixture was stirred for one hour, then poured onto ice/water and extracted with ethyl acetate. The extracts yielded an oil which was distilled under vacuum to give 2,2-dimethyl-1-(2-chlorophenyl)cyclobutane carbonitrile, (b.p. 116°-120° C./1 mbar) which was recrystallised from petroleum ether (b.p. 60°-80° C.) m.p. 65°-69° C.

Provenance & Evidence