Thionyl Chloride → 5-Fluoro-2-nitrobenzoyl chloride

HRID 440545Notes

Reaction equation

HRID 440545 reaction equation
[F:1][C:2]1[CH:3]=[CH:4][C:5]([N+:11]([O-:13])=[O:12])=[C:6]([CH:10]=1)[C:7](O)=[O:8].S(Cl)([Cl:16])=O>>[F:1][C:2]1[CH:3]=[CH:4][C:5]([N+:11]([O-:13])=[O:12])=[C:6]([CH:10]=1)[C:7]([Cl:16])=[O:8]

Participants

3

Reactant 2

HCID 24386Thionyl ChlorideHCID 27374205-Fluoro-2-nitrobenzoic acid

Product 1

HCID 156548685-Fluoro-2-nitrobenzoyl chloride

Procedure

A mixture of 5-fluoro-2-nitrobenzoic acid (47.51 g, 0.257 mol) and thionyl chloride (100 mL, 1.370 mol) is refluxed for several hours and concentrated in vacuo to give the title product which is used in Example 2 without further purification.

Workup

  1. temperatureis refluxed for several hours
  2. concentrationconcentrated in vacuo

Sources & evidence

ORD record
ord-70ccdffa04114e61ac4c315fc95d404c
Source dataset
uspto-grants-1996_05
Patent number
US05519133

Reaction notes

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