Hydrochloric Acid → 2-Methyl-5-(4-chlorobenzylidene)-cyclopentanone

Participants

Reaction Conditions

Reaction Steps

A solution of 12 g of sodium hydroxide in 20 ml of water was added to 10 g of methyl 3-(4-chloro-benzylidene)-1-methyl-2-oxocylopentanecarboxylate (I-1) (prepared in Example 1). The mixture was stirred for 2 hours at 80° C. The reaction mixture was poured into 10% aqueous solution of hydrochloric acid and extracted with ethyl acetate. The organic layer was washed with water and dried over anhydrous sodium sulfate. The solvent was evaporated to obtain 4.1 g of an oily matter (yield, 51.8%).

Provenance & Evidence