Sodium Hydroxide → HCID 9844690, compound

Participants

Reaction Steps

500 mg (1.1 mMol) of 2-n-propyl-4-methyl-1-[4-[(α-ethoxycarbonyl)benzyloxy]benzyl]benzimidazole are dissolved in 10 ml of ethanol and mixed with 10 ml of 1N sodium hydroxide solution. The mixture is stirred at ambient temperature for 30 minutes. Then the mixture is concentrated by evaporation and taken up in water. The solution is acidified by the addition of glacial acetic acid. The precipitate formed is suction filtered, washed with water until neutral and dried. The crude product is taken up in methylene chloride and purified over a silica gel column (particle size 0.063-0.02 mm), using as eluant a mixture of methylene chloride and methanol (19: 1). The uniform fractions are concentrated by evaporation in vacuo and the residue is triturated with hexane/ether and suction filtered.

Provenance & Evidence