Sodium hydride → HCID 53901140, compound

Participants

Reaction Steps

2.0 g of allyl 2,6-dihydroxybenzoate (V) was added to the suspension of 0.4 g of sodium hydride in 50 ml of dimethylformamide and the mixture was stirred for 10 minutes. To this mixture was added 2.2 g of 4,6-dimethoxy-2-methylsulfonylpyrimidine. The reaction mixture was stirred for 5 hours and 50 ml of saturated ammonium chloride solution was added thereto. The reaction solution was then extracted with 200 ml of ethylacetate. The extract was dried over anhydrous sodium sulfate and then distilled under reduced pressure to remove the solvent. The residue was subjected to column chromatography (hexane:ethylacetate=2:1 v/v) on silica gel to obtain 3.0 g (Yield 90%) of the title compound.

Provenance & Evidence