HuagongsheHuagongshe Chemistry Print Report · For research reference only
Diphosgene → 5-chloro-3,4-dihydro-7-fluoro-2H-1-benzopyran-8-yl isocyanate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Diphosgene | HCID 10426 | — |
| Reactant | 8-amino-5-chloro-3,4-dihydro-7-fluoro-2H-1-benzopyran | HCID 22404792 | — |
| Solvent | Toluene | HCID 1140 | — |
| Product | 5-chloro-3,4-dihydro-7-fluoro-2H-1-benzopyran-8-yl isocyanate | HCID 22404728 | 99.8% |
Reaction Steps
By the method of Example 1, Step F, 2.2 grams (0.011 mole) of 8-amino-5-chloro-3,4-dihydro-7-fluoro-2H-1-benzopyran and 2.2 grams (0.011 mole) of trichloromethyl chloroformate were reacted in 50 mL of toluene, yielding about 2.5 grams of 5-chloro-3,4-dihydro-7-fluoro-2H-1-benzopyran-8-yl isocyanate. The product was taken to the next step without further characterization.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05521147 |
| Source dataset | uspto-grants-1996_05 |
| ORD ID | ord-b7d53091fdd84250941e45a98eafb287 |
| Source note | uspto-grants-1996_05 |