Chlorosuccinimide → HCID 22404752, compound

Participants

Reaction Steps

By a method analogous to that of Example 11, Step J, 1.5 grams (0.0008 mole) of 8-amino-2,2-dimethyl-7-fluoro-2H-1-benzopyran was reacted with 1.1 grams (0.008 mole) of N-chlorosuccinimide in 50 mL of N,N-dimethylformamide. The crude reaction product was purified with column chromatography on silica gel, with hexane and 1:1 methylene chloride:hexane hexane as the eluants. The product-containing fractions were combined and concentrated under reduced pressure, yielding 0.6 gram of 8-amino-5-chloro-2,2-dimethyl-7-fluoro-2H-1-benzopyran. The NMR spectrum was consistent with the proposed structure.

Provenance & Evidence