Methyl iodide → HCID 22404729, compound

Participants

Reaction Steps

By the method of Example 1, Step G, 4.0 grams (0.016 mole) of 5-chloro-3,4-dihydro-2,2-dimethyl-7-fluoro-2H-1-benzopyran-8-yl isocyanate was reacted with 1.0 gram (0.023 mole) of sodium hydride and 3.0 grams (0.017 mole) of ethyl 3-amino-4,4,4-trifluorocrotonate in 150 mL of tetrahydrofuran. Subsequently, 4.5 grams (0.032 mole) of methyl iodide and 4.4 grams (0.032 mole) of potassium carbonate were reacted with the product of the first reaction, yielding 2.4 grams of 3-(5-chloro-3,4-dihydro-2,2-dimethyl- 7-fluoro-2H-1-benzopyran-8-yl)-1-methyl-6-trifluoromethyluracil, mp 132°-135° C. The NMR spectrum was consistent with the proposed structure.

Provenance & Evidence