Hexane → HCID 22404779, compound

Participants

Reaction Steps

By the method of Example 3, Step A, 1.8 grams (0.004 mole) of 3-(5-chloro-3,4-dihydro-2,2-dimethyl-7-fluoro-2H-1-benzopyran-8-yl)-1-methyl-6-trifluoromethyluracil was reacted with 3.5 grams (0.013 mole) of potassium persulfate and 1.1 grams (0.004 mole) of copper(II) sulfate pentahydrate in 30 mL of acetonitrile and 30 mL of water. The crude reaction mixture was subjected to column chromatography on silica gel, with 1:4 ethyl acetate:hexane as the eluant. The product-containing fractions were combined and concentrated under reduced pressure, yielding 0.8 gram of 3-(5-chloro-3,4-dihydro-2,2-dimethyl-7-fluoro-2H-1-benzopyran-4-on-8-yl)-1-methyl-6-trifluoromethyluracil. The NMR spectrum was consistent with the proposed structure.

Provenance & Evidence